I am using a Newbeedrone Infinity AIO V2 with the dual gyros, and I think something having to do with that is throwing me off.  Props are on correctly, motor direction is correct and the on-screen model moves the correct way in the setup, but when I throttle, the quad will start to take off, then throttle kinda hard and flip out.  

The weird thing with this board is that the power leads are meant to come out to one side.  In my build, it would be better if the leads came out the back so did so, and rotated the board 270 degrees on yaw in Betaflight.  First and second gyros are set to default.  I'm considering just setting it to use one of the gyros but am not sure if that's the right move.  I'm also confused as to if I'm supposed to change rotation on the gyro itself or on board and sensor alignment?

You should only need to change the "yaw rotation."

Darn... Then I'm at a loss, since that's what I did. I may just reflash the board and start over. I also remapped the motors to what the on-screen diagram shows, which I'm assuming I'm supposed to do.

Change the yaw rotation first. Make sure the new board movements are the same as the 3D model. Then remap your motors accordingly. Test your motors are in the correct position and spinning the right direction.

Yep, I've done all of that.

EDIT: I found on Newbeedrone's page for the AIO that the suggested ESC's settings are different from how it comes - frequency low is supposed to be at 96KHZ (comes at 24) and Frequency high is supposed to be at "By RPM" (comes at 24KHZ). I'm wondering if this could be the problem? It's raining all day today so I can't test. Thoughts?

I am not sure if you read Oscar's regarding the Low and High frequency settings. Have a read. It does sounds like your motors are desyncing and not an orientation issue. Considering that you were able to actually takeoff a bit.

https://oscarliang.com/best-blheli-32-settings/

I see now, thank you. I will try Oscar's settings and see if they work. I found it odd that Newbeedrone didn't ship the board with those settings and instead put instructions to change things...almost like others had issues too.

Voodoo - I found a guide you made on PID loop frequency and Gyro update frequency, and noticed this board is on 3.2khz for both, but on Dshot600 and bidirectional turned on. I switched that to Dshot 300, and also noticed the number of motor poles was set to 14, while my motors are 12 so I changed that as well. Will give it a test tomorrow.

Motor poles is motor specific. What motors are you using?

Just a bit of warning: I am not sure how relative my guide still is now. But I can't image it has changed too much.

And before you start to try all these settings change, make sure you don't have a cold solder on one of your motor wire.

I was wrong, they are 14. I was looking at tthe number of coils, not magnets. Also checked and no cold solder.

Tested this morning and it takes off and flies ok, just terribly, likely because it's a bottom mount and an oddly shaped frame. So it should be just a matter of setting the motor poles back to 14 and tuning. Will check in PidToolbox when I get home.

Thank you for your help, Voodoo!

Great that it is flying. A bad tune could also be desyncing the motor. But BF usually flies relatively well with default PID.